Mechanistic insights revealed by the crystal structure of a histidine kinase with signal transducer and sensor domains.
Two-component systems (TCSs) are important for the adaptation and survival of bacteria and fungi under stress conditions.A TCS is often composed of a membrane-bound sensor histidine kinase (SK) and a response regulator (RR), which are relayed through sequential phosphorylation steps.However, the mechanism for how an SK is switched on in response to