MECHANISTIC INSIGHTS REVEALED BY THE CRYSTAL STRUCTURE OF A HISTIDINE KINASE WITH SIGNAL TRANSDUCER AND SENSOR DOMAINS.

Mechanistic insights revealed by the crystal structure of a histidine kinase with signal transducer and sensor domains.

Two-component systems (TCSs) are important for the adaptation and survival of bacteria and fungi under stress conditions.A TCS is often composed of a membrane-bound sensor histidine kinase (SK) and a response regulator (RR), which are relayed through sequential phosphorylation steps.However, the mechanism for how an SK is switched on in response to

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Rumination in major depressive disorder is associated with impaired neural activation during conflict monitoring

Individuals with major depressive disorder (MDD) often ruminate about past experiences, especially those with negative content.These repetitive thoughts may interfere with cognitive processes related to attention and conflict monitoring.However, the temporal nature of these processes as reflected in event-related potentials (ERPs) has not been well

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Interactive Affection of Pre-Pregnancy Overweight or Obesity, Excessive Gestational Weight Gain and Glucose Tolerance Test Characteristics on Adverse Pregnancy Outcomes Among Women With Gestational Diabetes Mellitus

PurposeTo examine the combined effect of pre-pregnancy overweight or obesity, excessive gestational weight gain, and glucose tolerance status on the incidence of adverse pregnancy read more outcomes among women with gestational diabetes mellitus.MethodsA observational study including 5529 gestational diabetes mellitus patients was performed.Logisti

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